0307 Day and night light exposure are associated with psychiatric disorders: An objective light study in >80,000 people

Abstract Introduction Circadian rhythm disturbance is a common feature of many psychiatric disorders. Light the primary input to circadian clock, with daytime light strengthening rhythms and night disrupting them. Therefore, habitual exposure may represent an environmental risk factor for susceptibility Methods We performed largest to-date cross-sectional analysis light, sleep, physical activity, mental health in participants from UK Biobank actigraphy cohort (n = 86,772 adults; aged 62.4 ± 7.4 years; 57% women). examined independent association day intensity covariate-adjusted disorders self-harm. Results Greater was associated increased major depressive disorder, generalized anxiety PTSD, psychosis, bipolar Independent greater reduced These findings were robust adjustment sociodemographics, photoperiod, sleep quality. Conclusion Our demonstrate that low bright are wide range outcomes. Avoiding at seeking during be simple effective, non-pharmacological means broadly improving health. Support (if any)